Paul Benke, MD

Specialties
Pediatric Genetics
Primary Office
Address 1131 N 35th Avenue
2nd Floor
Hollywood, FL 33021

About Me

Medical Director, Clinical Genetics

Dr. Paul Benke is Director of Clinical Genetics at Joe DiMaggio Children's Hospital. He earned his medical degree at the University of Pennsylvania and his PhD from the University of Wisconsin at Madison, where he received his pediatric training, and was a research fellow supported by the National Institutes of Health. Prior to joining Joe DiMaggio Children's Hospital, Dr. Benke was the director of Clinical Genetics at the University of Miami School of Medicine, where he also served as associate professor in the department of biochemistry and molecular biology. He is the senior geneticist in practice in South Florida.

Dr. Benke is the most experienced geneticist in South Florida. He has experience caring for patients in the clinical genetics setting as well as participating in numerous research studies, publications, educating future doctors and other academic endeavors. Dr. Benke has discovered various genetic conditions including Cayman Ataxia, X-linked Leigh's Syndrome, a recessive form of Adrenoleukodystrophy, and more recently SLC5A6 Related Disorder. He was also involved in describing the initial cases of Pallister-Hall Syndrome. While completing his PhD work he was the first to discover the devastating harmful effects of Accutane in pregnancy and performed extensive research studies on Lesch Nyhan Syndrome.

Dr. Benke's love for learning and genetics will never cease. He continually attends the American Society of Human Genetics annual meetings and stays current on new developments and treatments in the genetics field. He has appeared on the TV show “Mystery Diagnosis” as well as CNN. He has been named one of America's Top Doctors in addition to Florida's Top Doctors, among other accolades.

His favorite past time is discovering treatable genetic basis for autism and other neurodevelopmental disorders. Nothing makes Dr. Benke happier than being able to provide a potential medical solution to a patient's concerns. While sometimes genetics can sound like a foreign language, Dr. Benke is there to explain everything to you and support you throughout the genetic evaluation and diagnostic process.

When Dr. Benke isn't in the office he enjoys spending time with his wife, daughters and grandchildren. He is still an active cyclist and enjoys sports and country music.

Related Medical Services

Education

Education
  • University Of Pennsylvania School Of Medicine, 1965
Residencies
  • University Of Wisconsin Hospital And Clinic, 1970, Pediatrics
Certifications
American Board of Medical Genetics and Genomics-Clinical Biochemical Genetics
American Board of Medical Genetics and Genomics-Clinical Genetics
American Board of Pediatrics-Pediatrics

Achievements

Publications

Abstracts

  • “Genome-wide Oligonuceotide Array CGH on Patients with Syndromic Autism Disorders Revealed High Frequency of Large Copy Number Variations,” American College of Medical Genetics, 2008
  • “Mutation A1632E of NaV1.7 in Paroxysmal Extreme Pain Disorder Alters Gating Properties and Promotes Repetitive Firing in DRG and Trigeminal Ganglion Neurons,” Society of Neuroscience, 2008
  • “Losartan for Ehlers Danlos IV,” American Society of Human Genetics Meeting, Honolulu, HI, 2009
    “Array CGH Detection of UBE3A Single-Gene Deletion Associated with Angelman Syndrome,” American Society of Human Genetics Meeting, Honolulu, HI, 2009
  • “Microdeletion Syndrome Case Series, Including Parent-to-Child Transmission, Endrocrinologic Disorder, and an Anerphric Infant,” American College of Medical Genetics, 2009
  • Ghaffari, G., Benke, P.J., Yusupov, R., Ilagan, B.J., Hung, C., Hosseini, S.A., Brenton, L., Rodriguez, M., Johnson B., and Bodamer, O.A. Characterization of Copy Number Variation and Loss of Heterozygosity Using high resolution SNP Microarray – The Miami Experience. American Society of Human Genetics Meeting 2014, San Diego
  • Benke, PJ: Combination Biotin Responsive Encephalopathy and Hemiplegic Migraine Disorder presenting as autism and episodic limb dysfunction/seizures in a 10 year old girl. American Society of Human Genetics Meeting 2014, San Diego
  • Benke, PJ, Parikh, SA, Braffman, B, Chang, C. Cofactors biotin, pantothenic acid, and lipoic acid dramatically improved the health of a child with SLC5A6 gene defect, but not natural killer T-cell function, leading to an ALTE with brain damage and loss of gained skills. American Society of Human Genetics Annual Meeting 2019, Houston

Articles

  • Opitz, J.M., Richieri-da Costa, A, Aase, J.M., and Benke, P.J.: FG syndrome update 1988: Note of 5 New Patients and Bibliography Am J. Med. Genet. 30.:309-28, 1988
  • Benke, P.J. Molecular, metabolic and immune evidence suggests that systemic autoimmune disease is antigen mediated. Medical Hypotheses. 47(5); 337-46, 1996
  • Shaffer, L.G., Kashork, C.D. Benke, P.J., Bacino, C.A.: Caution: Telomere Crossing. Amer. J. Med. Genetics 87:278-80, 1999
  • Glinton, K., Benke, P.J., Lines, M., Geraghty, M., Chakraborty, P., Al-Dirbashi, OY., Sutton, OR., Elsea, SJ., El-Hattab, AY, Disturbed phospholipid metabolism in serine biosynthesis defects revealed by metabolomics profiling. Molecular Genetics and metabolism. 2017 Dec 12. Pii:S1096-7192 (17)30654-6. doi: 10.1016/j.ymgme.2017.12.009 [ Epub ahead of print] PMID: 2929105
  • Van Dijck A, Vulto-van Silfhout AT, Cappuyns E, & ADNP study group including Benke PJ & others: Clinical  presentation of a complex neurodevelopmental disorder caused by mutations in ADNP. Bio Psychiatry. 2018 Mar 15. Pii: S0006-3223(18)31303-9. Doi: 10.1016/j.biopsych. 2018.02.1173.[Epub ahead of print]
  • Liu P, Meng L, Normand EA, Xia F, Song X, Ghazi A, Rosenfeld J, Magoulas PL, Braxton A, Ward P, Dai H, Yuan B, Bi W, Xiao R, Wang X, Chiang T, Vetrini F, He W, Cheng H, Dong J, Gijavanekar C, Benke PJ, Bernstein JA, Eble T, Eroglu Y, Erwin D, Escobar L, Gibson JB, Gripp K, Kleppe S,
  • Koenig MK, Lewis AM, Natowicz M, Mancias P, Minor L, Scaglia F, Schaaf CP, Streff H, Vernon H, Uhles CL, Zackai EH, Wu N, Sutton VR, Beaudet AL, Muzny D, Gibbs RA, Posey JE, Lalani S, Shaw C, Eng CM, Lupski JR, Yang Y. Reanalysis of Clinical Exome Sequencing Data. N Engl J Med. 2019 Jun 20;380(25):2478-2480. doi: 10.1056/NEJMc1812033.
     

Articles

  • Opitz, J.M., Richieri-da Costa, A, Aase, J.M., and Benke, P.J.: FG syndrome update 1988: Note of 5 New Patients and Bibliography Am J. Med. Genet. 30.:309-28, 1988
  • Benke, P.J. Molecular, metabolic and immune evidence suggests that systemic autoimmune disease is antigen mediated. Medical Hypotheses. 47(5); 337-46, 1996
  • Shaffer, L.G., Kashork, C.D. Benke, P.J., Bacino, C.A.: Caution: Telomere Crossing. Amer. J. Med. Genetics 87:278-80, 1999
  • Glinton, K., Benke, P.J., Lines, M., Geraghty, M., Chakraborty, P., Al-Dirbashi, OY., Sutton, OR., Elsea, SJ., El-Hattab, AY, Disturbed phospholipid metabolism in serine biosynthesis defects revealed by metabolomics profiling. Molecular Genetics and metabolism. 2017 Dec 12. Pii:S1096-7192 (17)30654-6. doi: 10.1016/j.ymgme.2017.12.009 [ Epub ahead of print] PMID: 2929105
  • Van Dijck A, Vulto-van Silfhout AT, Cappuyns E, & ADNP study group including Benke PJ & others: Clinical  presentation of a complex neurodevelopmental disorder caused by mutations in ADNP. Bio Psychiatry. 2018 Mar 15. Pii: S0006-3223(18)31303-9. Doi: 10.1016/j.biopsych. 2018.02.1173.[Epub ahead of print]

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