Paul Benke, MD

Pediatric Genetics
Primary Office
Address 1131 N 35th Avenue
2nd Floor
Hollywood, FL 33021

About Me

Medical Director, Clinical Genetics

Dr. Paul Benke is Director of Clinical Genetics at Joe DiMaggio Children’s Hospital. He earned his medical degree at the University of Pennsylvania and his PhD from the University of Wisconsin at Madison, where he received his pediatric training, and was a research fellow supported by the National Institutes of Health. Prior to joining Joe DiMaggio Children’s Hospital, Dr. Benke was the director of Clinical Genetics at the University of Miami School of Medicine, where he also served as associate professor in the department of biochemistry and molecular biology. He is the senior geneticist in practice in South Florida. 

Dr. Benke has been widely published – including several new genetic disorders of metabolism and several new clinical genetic disorders. He has authored many juried journal articles, book chapters and scientific reports, articles and abstracts. He has served as a consultant for the Cayman Islands and the Bahamas, and has been on cable news and television.

Related Medical Services


  • University Of Pennsylvania School Of Medicine, 1965
  • University Of Wisconsin Hospital And Clinic, 1970, Pediatrics
American Board of Medical Genetics and Genomics-Clinical Biochemical Genetics
American Board of Medical Genetics and Genomics-Clinical Genetics
American Board of Pediatrics-Pediatrics



  • “Losartan for Ehlers Danlos IV,” American Society of Human Genetics Meeting, Honolulu, HI, 2009
  • “Array CGH Detection of UBE3A Single-Gene Deletion Associated with Angelman Syndrome,” American Society of Human Genetics Meeting, Honolulu, HI, 2009
  • “Microdeletion Syndrome Case Series, Including Parent-to-Child Transmission, Endrocrinologic Disorder, and an Anerphric Infant,” American College of Medical Genetics, 2009
  • “Genome-wide Oligonuceotide Array CGH on Patients with Syndromic Autism Disorders Revealed High Frequency of Large Copy Number Variations,” American College of Medical Genetics, 2008
  • “Mutation A1632E of NaV1.7 in Paroxysmal Extreme Pain Disorder Alters Gating Properties and Promotes Repetitive Firing in DRG and Trigeminal Ganglion Neurons,” Society of Neuroscience, 2008


  • Opitz, J.M., Richieri-da Costa, A, Aase, J.M., and Benke, P.J.: FG syndrome update 1988: Note of 5 New Patients and Bibliography Am J. Med. Genet. 30.:309-28, 1988
  • Benke, P.J. Molecular, metabolic and immune evidence suggests that systemic autoimmune disease is antigen mediated. Medical Hypotheses. 47(5); 337-46, 1996
  • Shaffer, L.G., Kashork, C.D. Benke, P.J., Bacino, C.A.: Caution: Telomere Crossing. Amer. J. Med. Genetics 87:278-80, 1999
  • Glinton, K., Benke, P.J., Lines, M., Geraghty, M., Chakraborty, P., Al-Dirbashi, OY., Sutton, OR., Elsea, SJ., El-Hattab, AY, Disturbed phospholipid metabolism in serine biosynthesis defects revealed by metabolomics profiling. Molecular Genetics and metabolism. 2017 Dec 12. Pii:S1096-7192 (17)30654-6. doi: 10.1016/j.ymgme.2017.12.009 [ Epub ahead of print] PMID: 2929105
  • Van Dijck A, Vulto-van Silfhout AT, Cappuyns E, & ADNP study group including Benke PJ & others: Clinical  presentation of a complex neurodevelopmental disorder caused by mutations in ADNP. Bio Psychiatry. 2018 Mar 15. Pii: S0006-3223(18)31303-9. Doi: 10.1016/j.biopsych. 2018.02.1173.[Epub ahead of print]

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